Related Experiment Video
Updated: Apr 18, 2026
Multi-Modal Home Sleep Monitoring in Older Adults
Published on: January 26, 2019
Objectively Measured Sleep and β-amyloid Burden in Older Adults: A Pilot Study
Adam P Spira1, Christopher Yager2, Jason Brandt3
1Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD ; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD.
Background/Aims:
Although disturbed sleep is associated with cognitive deficits, the association between sleep disturbance and Alzheimer's disease (AD) pathology is unclear. In this pilot study, we examined the extent to which sleep duration, sleep quality, and sleep-disordered breathing (SDB) are associated with β-amyloid (Aβ) deposition in the brains of living humans.
Methods:
We studied 13 older adults (8 with normal cognition and 5 with mild cognitive impairment (MCI)). Participants completed neuropsychological testing, polysomnography and Aβ imaging with [11C]-Pittsburgh compound B.
Results:
Among participants with MCI, higher apnea-hypopnea index and oxygen desaturation index were associated with greater Aβ deposition, globally and regionally in the precuneus. There were no significant associations between SDB and Aβ deposition among cognitively normal participants. There were no significant associations between sleep duration or sleep fragmentation and Aβ deposition.
Conclusion:
These preliminary results suggest that, among older adults with MCI, greater SDB severity is associated with greater Aβ deposition.
