Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

2.1K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-nitro-Containing Biocidal Compounds: Balancing the Energy and Biocidal Properties by Incorporating Furazans.

Organic letters·2026
Same author

Molecular basis of host ATP level modulation by actin-dependent secreted bacterial ATPase and its metaeffector.

Nature communications·2026
Same author

Inactivation of PETase at Interfaces Inhibits PET Plastic Depolymerization.

ACS sustainable chemistry & engineering·2026
Same author

Evidence summary: facial nerve rehabilitationtraining management for patients with peripheral facial paralysis.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Electrokinetic nanoparticle transport in an interconnected porous environment: Decoupling cavity escape and directional bias.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Sustainable recycling of spent ternary cathode materials via pomelo peel-mediated anaerobic roasting and low-acid leaching.

Journal of hazardous materials·2025
Same journal

Nongenetic <i>in Vivo</i> Bimodal Neuromodulation via Photothermal Gold Nanorods and a Multifunctional Fiber Neural Probe.

ACS nano·2026
Same journal

Electric-Field-Driven Ferredoxin 1-Independent Cuproptosis Induction Overcomes Therapy-Induced Resistance in Glioblastoma.

ACS nano·2026
Same journal

Connecting and Engaging.

ACS nano·2026
Same journal

Efficient Photocatalytic Methane Conversion to Liquid Oxygenates by Constructing Charge-Directed Transfer Pathways.

ACS nano·2026
Same journal

Mechanochemically Coupled Multidimensional Modulation of Calcium Overload.

ACS nano·2026
Same journal

Electrical Control and High-Bias Enhancement of Magnetoresistance in van der Waals Antiferromagnetic Spin-Filter Tunnel Field-Effect Transistor.

ACS nano·2026
See all related articles

Related Experiment Video

Updated: Apr 18, 2026

Expanding Nanopatterned Substrates Using Stitch Technique for Nanotopographical Modulation of Cell Behavior
09:06

Expanding Nanopatterned Substrates Using Stitch Technique for Nanotopographical Modulation of Cell Behavior

Published on: December 8, 2016

7.1K

Nanoscale topography influences polymer surface diffusion.

Dapeng Wang1, Chunlin He, Mark P Stoykovich

  • 1Department of Chemical and Biological Engineering, University of Colorado Boulder , Boulder, Colorado 80309, United States.

ACS Nano
|January 27, 2015
PubMed
Summary
This summary is machine-generated.

Polymer chains on nanopillar surfaces show unusual, intermittent movement. Their diffusion patterns change with pillar height, revealing insights into transport on patterned surfaces.

Keywords:
CTRWobstructed diffusionpolymersingle-molecule fluorescence imagingsurface diffusion

More Related Videos

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

8.6K
The Evolution of Silica Nanoparticle-polyester Coatings on Surfaces Exposed to Sunlight
10:27

The Evolution of Silica Nanoparticle-polyester Coatings on Surfaces Exposed to Sunlight

Published on: October 11, 2016

10.1K

Related Experiment Videos

Last Updated: Apr 18, 2026

Expanding Nanopatterned Substrates Using Stitch Technique for Nanotopographical Modulation of Cell Behavior
09:06

Expanding Nanopatterned Substrates Using Stitch Technique for Nanotopographical Modulation of Cell Behavior

Published on: December 8, 2016

7.1K
Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

8.6K
The Evolution of Silica Nanoparticle-polyester Coatings on Surfaces Exposed to Sunlight
10:27

The Evolution of Silica Nanoparticle-polyester Coatings on Surfaces Exposed to Sunlight

Published on: October 11, 2016

10.1K

Area of Science:

  • Surface science
  • Polymer physics
  • Nanotechnology

Background:

  • Understanding interfacial transport is crucial for nanotechnology.
  • Polymer diffusion on surfaces is influenced by surface topography.
  • Nanopillar arrays present complex environments for molecular motion.

Purpose of the Study:

  • To investigate the diffusion dynamics of poly(ethylene glycol) (PEG) chains.
  • To analyze the effect of nanopillar surface topography on polymer diffusion.
  • To elucidate the mechanisms of anomalous diffusion at liquid-solid interfaces.

Main Methods:

  • High-throughput single-molecule tracking was employed to monitor PEG chain movement.
  • Experiments were conducted on hydrophobic surfaces patterned with hexagonally arranged nanopillars of varying heights.
  • Kinetic Monte Carlo simulations of continuous-time random walk (CTRW) were used for data analysis.

Main Results:

  • PEG chains exhibited anomalous diffusion characterized by intermittent motion (immobilization and hopping).
  • This behavior was consistent with continuous-time random walk (CTRW) associated with desorption-mediated surface diffusion.
  • Diffusion became more subdiffusive with longer waiting times as nanopillar height increased.
  • Simulations incorporating permeable obstacles accurately described the observed trajectories, linking permeability to obstacle height.

Conclusions:

  • Nanotopography significantly alters interfacial polymer diffusion, leading to anomalous transport behaviors.
  • Continuous-time random walk (CTRW) models effectively capture diffusion dynamics in the presence of surface obstacles.
  • The findings offer new perspectives on molecular transport mechanisms on nanotopographically patterned surfaces.