Related Experiment Video
Updated: Apr 18, 2026

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
Published on: September 7, 2017
Hypomethylation of MAOA's first exon region in depression: a replication study
Philippe A Melas1, Yvonne Forsell2
1Department of Clinical Neuroscience, Karolinska Institutet, CMM L8:00, Karolinska University Hospital, 17176 Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Abstract:
We recently showed that depression in females is associated with hypomethylation in the first exon region of the monoamine oxidase A (MAOA) gene. Here we report on a small-scale (n=44) replication study of MAOA methylation which (a) confirms that female subjects with a history of depression are hypomethylated compared to controls and (b) shows that females are hypermethylated in the same region compared to males.
More Related Videos
14:56Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
13:47Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
Published on: March 29, 2019
Related Concept Videos
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Antidepressant Drugs: MAOIs and Other Agents