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Chiral 1,4-benzodiazepin-2-ones: relationship between stereochemistry and pharmacological activity
P Salvadori1, C Bertucci, E Domenici
1Centro di Studio del CNR per le Macromolecole Stereordinate Otticamente Attive, Dipartimento di Chimica e Chimica Industriale, Pisa, Italy.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1989
Abstract:
Pure enantiomers of 3-substituted-1,4-benzodiazepin-2-ones, obtained by HPLC resolution on chiral stationary phases, show significant differences in their pharmacological activity. The occurrence of biotransformation during the pharmacological test is monitored using a new chromatographic method. The reliability of the pharmacological activity data is discussed.