Insomnia with physiological hyperarousal is associated with hypertension
Yun Li1, Alexandros N Vgontzas2, Julio Fernandez-Mendoza1
1From the Sleep Medicine Center, Mental Health Center, Translational Neuroscience Center, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Y.L., Y.S., J.Z., R.R., T.L., X.T.) and Department of Psychiatry, Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, Hershey (Y.L., A.N.V., J.F.-M., E.O.B.).
Hypertension (Dallas, Tex. : 1979)
|January 28, 2015
Summary
Chronic insomnia with physiological hyperarousal, measured by a long Multiple Sleep Latency Test (MSLT), significantly increases hypertension risk. Longer MSLT values indicate greater risk.
Area of Science:
- Sleep Medicine
- Cardiovascular Health
- Physiology
Background:
- Insomnia with short sleep duration is linked to hypertension risk.
- Physiological hyperarousal is a suspected underlying mechanism.
- Objective measures of hyperarousal in insomnia require further investigation.
Purpose of the Study:
- To determine if insomnia with physiological hyperarousal, assessed by MSLT, is associated with an increased risk of hypertension.
- To investigate MSLT as a biomarker for hypertension risk in chronic insomniacs.
Main Methods:
- Study included 219 chronic insomniacs and 96 normal sleepers.
- Polysomnography followed by Multiple Sleep Latency Test (MSLT) was performed.
- Hyperarousal defined by MSLT values >14 minutes (median) or >17 minutes (75th percentile).
Main Results:
- Insomnia with MSLT >14 minutes elevated hypertension odds by 300% (OR=3.27).
- Insomnia with MSLT >17 minutes elevated hypertension odds by 400% (OR=4.33).
- These associations remained significant after controlling for confounding factors.
Conclusions:
- Insomnia associated with physiological hyperarousal presents a significant hypertension risk.
- Long MSLT values serve as a reliable index of hyperarousal and insomnia severity.
- Objective sleepiness measures may predict cardiovascular risk in insomnia patients.
Keywords:
hypertensioninsomniamultiple sleep latency testphysiological hyperarousalsleepsleep initiation and maintenance disordersMore Related Videos
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