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Repercussions of NSAIDS drugs on bone tissue: the osteoblast

O García-Martínez1, E De Luna-Bertos1, J Ramos-Torrecillas1

  • 1Biomedical Group (BIO277), Faculty of Health Sciences, University of Granada, Instituto Investigación Biosanitaria, ibs.Granada, Spain.

Life Sciences
|January 28, 2015
PubMed

Insights

Non-steroidal anti-inflammatory drugs (NSAIDs) negatively impact bone repair by harming osteoblast function. Careful NSAID selection is crucial for patients needing bone tissue regeneration.

Area of Science:

  • Orthopedics
  • Pharmacology
  • Cell Biology

Background:

  • Non-steroidal anti-inflammatory drugs (NSAIDs) influence osteoblast behavior, crucial for bone repair.
  • The specific effects of NSAIDs on osteoblasts vary, necessitating a clear understanding for clinical application.

Purpose of the Study:

  • To review and synthesize current literature on NSAID effects on osteoblasts since 2001.
  • To provide guidance on selecting appropriate NSAIDs for patients undergoing bone tissue repair.

Main Methods:

  • Comprehensive literature search of MEDLINE, EMBASE, and Cochrane Library databases.
  • Inclusion of studies published from 2001 onwards.
  • Keywords: bone tissue, osteoblast, NSAIDs, Anti-inflammatory drugs.

Main Results:

  • Most NSAIDs adversely affect osteoblast proliferation via cell cycle arrest and apoptosis.
  • NSAID impact on osteoblast differentiation is drug-, dose-, and time-dependent.
  • Some NSAIDs, like indomethacin and diclofenac, increase osteoblast adhesion and decrease migration.

Conclusions:

  • NSAIDs generally exert adverse effects on bone tissue, impacting osteoblast function.
  • The role of osteoblasts in bone repair highlights the importance of considering NSAID-induced effects.
  • Clinical decisions regarding NSAID use in bone repair should account for their potential negative impact on osteoblasts.
Keywords:
Anti-inflammatory drugsBoneNSAIDsOsteoblast

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