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Updated: Apr 18, 2026
Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
Published on: February 23, 2020
Autism spectrum disorders: linking neuropathological findings to treatment with transcranial magnetic stimulation
Manuel F Casanova1, Estate Sokhadze, Ioan Opris
1Department of Psychiatry, University of Louisville, Louisville, KA, USA.
Unlabelled:
Postmortem studies in autism spectrum disorder (ASD) individuals indicate the presence of abnormalities within the peripheral neuropil space (PNS) of cortical minicolumns. The geometrical orientation of inhibitory elements within the PNS suggests using repetitive transcranial magnetic stimulation (rTMS) to up-regulate their activity. Several rTMS trials in ASD have shown marked improvements in motor symptomatology, attention and perceptual binding.
Conclusion:
rTMS is the first therapeutic attempt at ASD aimed at correcting some of its core pathology.
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