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Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization

Yirui Guo1, Thomas H Scheuermann1, Carrie L Partch1

  • 1From the Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8816 and.

The Journal of Biological Chemistry
|January 29, 2015
PubMed
Summary

Hypoxia-inducible factor (HIF) complexes recruit coiled-coil coactivators (CCCs) like TACC3 to regulate gene expression during hypoxic stress. This study reveals how TACC3 bridges HIF-2α and ARNT PAS-B domains, impacting HIF-dependent transcription.

Keywords:
ARNTCoiled-coil Coactivator RecruitmentCrystal StructureHypoxia-inducible Factor (HIF)Nuclear Magnetic Resonance (NMR)TACC3Transcription CoactivatorTranscription Regulation

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