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Updated: Apr 18, 2026
Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol
Published on: October 27, 2023
The effects of binge-pattern alcohol consumption on orthodontic tooth movement
Cristiano Miranda de Araujo1, Aline Cristina Batista Rodrigues Johann2, Elisa Souza Camargo2
1Catholic University of Paraná.
Objective:
This study aimed to assess tissue changes during orthodontic movement after binge-pattern ethanol 20% exposure.
Methods:
Male Wistar rats (n = 54) were divided into two groups. The control group (CG) received 0.9% saline solution, while the experimental group (EG) received 20% ethanol in 0.9% saline solution (3 g/kg/day). On the 30th day, a force of 25 cN was applied with a nickel-titanium closed coil spring to move the maxillary right first molar mesially. The groups were further divided into three subgroups (2, 14 and 28 days). Tartrate-resistant acid phosphatase and picrosirius were used to assess bone resorption and neoformation, respectively. Data were compared by two-way ANOVA, Tukey's HSD, Games-Howell and chi-square test. Significance level was set at 5%.
Results:
There was a decrease in the number of osteoclasts in EG at day 28. The percentage of collagen showed no interaction between group and time.
Conclusion:
Binge-pattern 20% ethanol promoted less bone resorption at the end of tooth movement, thereby suggesting delay in tooth movement.
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