Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

3.5K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Use of B-cell Tetramers for the Study of Trypanosoma cruzi-Specific B cells.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Differential Response and Recovery Dynamics of HSPC Populations Following <i>Plasmodium chabaudi</i> Infection.

International journal of molecular sciences·2025
Same author

Evidence of Plasmodium vivax circulation in western and eastern regions of Senegal: implications for malaria control.

Malaria journal·2024
Same author

Distinct ontogenetic lineages dictate cDC2 heterogeneity.

Nature immunology·2024
Same author

Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected.

BMC infectious diseases·2024
Same author

Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T<sub>reg</sub> depletion.

Science immunology·2023

Related Experiment Video

Updated: Apr 18, 2026

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
08:46

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

18.6K

CD4 T-cell subsets in malaria: TH1/TH2 revisited.

Damian Perez-Mazliah1, Jean Langhorne1

  • 1Division of Parasitology, MRC National Institute for Medical Research , London , UK.

Frontiers in Immunology
|January 29, 2015
PubMed
Summary

CD4(+) T-cells are crucial for controlling Plasmodium parasites, with distinct roles in acute and chronic infections. Recent findings reveal multifunctional T-cells and follicular helper T-cells (Tfh) are key to immune responses and malaria control.

Keywords:
CD4 T-cell subsetsPlasmodiumTfhTh1Th2Th22malariamultifunctional CD4 T-cells

More Related Videos

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection
08:14

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

Published on: October 6, 2015

10.8K
In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes
08:20

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Published on: August 17, 2022

2.8K

Related Experiment Videos

Last Updated: Apr 18, 2026

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
08:46

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

18.6K
An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection
08:14

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

Published on: October 6, 2015

10.8K
In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes
08:20

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Published on: August 17, 2022

2.8K

Area of Science:

  • Immunology
  • Infectious Diseases
  • Parasitology

Background:

  • CD4(+) T-cells are central to controlling Plasmodium parasite infections.
  • Both IFN-γ production and B-cell help by CD4(+) T-cells are vital for eliminating infected red blood cells.
  • CD4(+) T-cells also control pre-erythrocytic stages by activating CD8(+) T-cells, but excessive inflammation can cause pathology.

Purpose of the Study:

  • To review and update the understanding of CD4(+) T-cell responses during Plasmodium infection.
  • To re-evaluate the classical Th1/Th2 paradigm in light of new discoveries.
  • To highlight the roles of multifunctional T-cells and follicular helper T-cells (Tfh).

Main Methods:

  • Review of existing literature on CD4(+) T-cell responses in Plasmodium infections.
  • Analysis of classical Th1/Th2 responses versus contemporary findings.
  • Inclusion of recent data on multifunctional T-cells and Tfh cells.

Main Results:

  • Classical Th1 responses are important for acute infection control but contribute to pathology.
  • IL-4 producing Th2 cells are not critical during the chronic phase; IL-4-independent B-cell help is essential.
  • Multifunctional T-cells (e.g., IFN-γ and IL-10 co-producing) and Tfh cells are key players.
  • IL-10 plays a protective role against severe malaria-associated inflammation.

Conclusions:

  • The understanding of CD4(+) T-cell subsets and their functions in Plasmodium infection has evolved beyond the simple Th1/Th2 model.
  • Follicular helper T-cells (Tfh) are the primary CD4(+) T-cell subset providing help to B-cells.
  • CD4(+) T-cell plasticity and the emergence of multifunctional cells offer a more nuanced view of immune control and pathology in malaria.