Related Experiment Video

Updated: Apr 18, 2026

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
11:06

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

6.6K

Regulation of IGF -1 signaling by microRNAs

Hwa Jin Jung1, Yousin Suh2

  • 1Department of Genetics, Albert Einstein College of Medicine New York, NY, USA.

Frontiers in Genetics
|January 29, 2015
PubMed

Insights

MicroRNAs (miRNAs) regulate the insulin-like growth factor 1 (IGF-1) signaling pathway, which is crucial for development and aging. Targeting these miRNAs offers potential therapeutic strategies for diseases linked to IGF-1 pathway dysregulation.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • The insulin-like growth factor 1 (IGF-1) signaling pathway is vital for development, homeostasis, and aging.
  • Its dysregulation is linked to diseases like cancer, neurodegeneration, and metabolic disorders.
  • MicroRNAs (miRNAs), small non-coding RNAs, regulate gene expression and are implicated in disease.

Purpose of the Study:

  • To review components of the IGF-1 signaling pathway targeted by miRNAs.
  • To highlight recent studies on the therapeutic potential of miRNAs in IGF-1-related diseases.

Main Methods:

  • Literature review of studies on miRNA regulation of IGF-1 signaling.
  • Analysis of research linking miRNA function to disease mechanisms.
  • Identification of therapeutic strategies involving miRNAs.

Main Results:

  • Identified key IGF-1 pathway components that are targets of miRNA regulation.
  • Highlighted emerging research demonstrating miRNA's role in modulating IGF-1 signaling.
  • Showcased the therapeutic potential of specific miRNAs for various diseases.

Conclusions:

  • miRNAs are significant regulators of the IGF-1 signaling pathway.
  • miRNA-based therapeutics show promise for treating diseases associated with IGF-1 pathway dysregulation.
Keywords:
IGF-1 signalingagingaging-related diseasemicroRNAstherapeutic agents

More Related Videos

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

18.1K
Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

9.0K

Related Concept Videos

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
11.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.1K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
3.0K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
6.5K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.4K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.9K