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C-P bond-forming reactions via C-O/P-H cross-coupling catalyzed by nickel
Jia Yang1, Tieqiao Chen, Li-Biao Han
1State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University , Changsha 410082, China.
Abstract:
The first Ni-catalyzed C-O/P-H cross-coupling producing organophosphorus compounds is disclosed. This method features wide generality in regard to both C-O and P-H compounds: for C-O compounds, the readily available alcohol derivatives of aryl, alkenyl, benzyl, and allyl are applicable, and for P-H compounds, both >P(V)(O)H compounds (secondary phosphine oxide, H-phosphinate, and H-phosphonate) and hydrogen phosphines (>P(III)H) can be used as the substrates. Thus, a variety of valuable C(sp(2))-P and C(sp(3))-P compounds can be readily obtained in good to excellent yields by this new strategy.
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