Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrons01:10

Nephrons

9.9K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
9.9K
Renal Drug Excretion: Overview01:15

Renal Drug Excretion: Overview

1.1K
As primary excretory organs, the kidneys maintain homeostasis by removing waste substances from the bloodstream. They comprise over a million units called nephrons, which serve as the kidney's functional units.
A nephron consists of two primary structures: the renal corpuscle and the renal tubule. The renal corpuscle contains the glomerulus, a network of capillaries where the first step of renal excretion, glomerular filtration, occurs. Blood pressure forces water, ions, and small molecules...
1.1K
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

626
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
626
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

521
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
521
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

652
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
652
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

1.1K
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extracellular Vesicle Mitochondrial DNA Reflects Podocyte Mitochondrial Stress and Is Associated with Relapse in Nephrotic Syndrome.

International journal of molecular sciences·2025
Same author

Damage-Associated Molecular Patterns and Pattern Recognition Receptors in the Podocyte.

Journal of the American Society of Nephrology : JASN·2024
Same author

Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology.

Toxicologic pathology·2023
Same author

The Proteome of Circulating Large Extracellular Vesicles in Diabetes and Hypertension.

International journal of molecular sciences·2023
Same author

High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury.

PloS one·2023
Same author

Parkin coregulates glutathione metabolism in adult mammalian brain.

Acta neuropathologica communications·2023
Same journal

Edaravone Dexborneol regulates the endothelial PPARγ-PON1 axis to inhibit high-cholesterol-induced atherosclerosis.

Clinical science (London, England : 1979)·2026
Same journal

HDAC9 promotes atherosclerosis by suppressing CYP7A1 and impairing hepatic cholesterol excretion.

Clinical science (London, England : 1979)·2026
Same journal

Clusterin ameliorates LPS-induced ARDS by inhibiting the Wnt/β-catenin pathway.

Clinical science (London, England : 1979)·2026
Same journal

Human cytomegalovirus at the maternal-fetal interface: an overview of pathogenesis, defence, and interventions.

Clinical science (London, England : 1979)·2026
Same journal

Cardiometabolic regulation by adipocyte-derived leptin and the brain melanocortin system.

Clinical science (London, England : 1979)·2026
Same journal

Impact of impaired branched-chain amino acid metabolism on kidney disease.

Clinical science (London, England : 1979)·2026
See all related articles

Related Experiment Video

Updated: Apr 18, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.5K

Nox and renal disease.

Chet E Holterman1, Naomi C Read2, Chris R J Kennedy1

  • 1*Department of Medicine, Division of Nephrology, Kidney Research Centre, Ottawa Hospital Research Institute, Ottawa, Canada.

Clinical Science (London, England : 1979)
|January 30, 2015
PubMed
Summary
This summary is machine-generated.

The Nox enzyme family is crucial for kidney function and contributes to renal pathologies through oxidative stress. This review highlights recent advances in understanding Nox roles in various kidney diseases, including diabetic nephropathy.

More Related Videos

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
09:40

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells

Published on: June 20, 2018

18.8K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

2.0K

Related Experiment Videos

Last Updated: Apr 18, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.5K
Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
09:40

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells

Published on: June 20, 2018

18.8K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

2.0K

Area of Science:

  • Nephrology
  • Molecular Biology
  • Biochemistry

Background:

  • Nox enzymes generate reactive oxygen species (ROS), playing vital roles in kidney physiology.
  • Nox enzymes, particularly Nox4, are implicated in renal pathologies like diabetic nephropathy via oxidative stress.
  • Growing evidence reveals other Nox family members' roles in diverse kidney diseases.

Purpose of the Study:

  • To review recent developments in renal Nox biology.
  • To emphasize the role of Nox enzymes in diabetic nephropathy and other renal diseases.
  • To highlight the contribution of Nox-derived oxidative stress to kidney pathologies.

Main Methods:

  • Literature review of studies on Nox enzymes in kidney physiology and pathology.
  • Analysis of research on Nox expression patterns and functions in renal cells.
  • Synthesis of findings linking Nox-derived ROS to renal disease mechanisms.

Main Results:

  • Nox enzymes are integral to normal kidney function and contribute to disease pathogenesis.
  • Nox-derived oxidative stress modifies lipids, proteins, and DNA, activating detrimental transcriptional programs.
  • Nox4 is a key player, but other Nox family members also have significant roles in various renal conditions.

Conclusions:

  • Nox enzymes are critical regulators of kidney health and disease.
  • Targeting Nox enzymes may offer therapeutic strategies for renal pathologies.
  • Further research into the diverse roles of Nox family members is essential for understanding and treating kidney diseases.