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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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Published on: February 6, 2019

Customized vaginal vault brachytherapy with computed tomography imaging-derived applicator prototyping.

Ericka Wiebe¹, Harry Easton², Gillian Thomas³

¹Department of Radiation Oncology, Cross Cancer Institute, Edmonton, AB, Canada.

|January 30, 2015

Summary

A new 3D-printed vaginal brachytherapy applicator offers improved treatment for complex anatomy. This custom mould technique enhances dose coverage in the vaginal vault, demonstrating clinical feasibility.

Keywords:

Custom applicator Image-derived prototyping Stereolithography Vaginal brachytherapy

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Area of Science:

Oncology
Medical Physics
Biomedical Engineering

Background:

Standard vaginal brachytherapy cylinders may provide suboptimal treatment for patients with irregular vaginal vault anatomy.
A customized applicator is needed to address anatomical variations and improve dose delivery accuracy.

Observation:

A novel image-guided technique utilizes CT imaging and stereolithography to create patient-specific vaginal brachytherapy moulds.
The custom applicator manufacturing process involves 3D digital modeling and additive layer-by-layer resin deposition.
Dosimetric measurements confirmed the accuracy of the custom applicator's density and delivered radiation dose.

Findings:

Stereolithography produced custom vaginal applicators with densities comparable to standard cylinders.
The custom applicators achieved accurate dose delivery, with measured doses within 4.2% of expected values.
Patient dosimetry showed significantly improved coverage of the lateral vaginal vault with custom applicators compared to standard cylinders.

Implications:

This 3D-printed brachytherapy mould technique offers a viable solution for treating complex vaginal vault anatomies.
The custom applicator enhances radiation dose distribution, potentially improving treatment outcomes in gynecological brachytherapy.
The demonstrated clinical feasibility supports the integration of additive manufacturing into gynecological radiation oncology workflows.