Related Experiment Video

Updated: Apr 18, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

525

microRNAs in breast cancer: regulatory roles governing the hallmarks of cancer

Jen N Goh1,2, Ser Y Loo1,3,4, Arpita Datta3

  • 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.

Biological Reviews of the Cambridge Philosophical Society
|January 30, 2015
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in breast cancer, influencing tumorigenesis and metastasis. This review explores their role as biomarkers for early detection and potential therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer complexity presents significant prevention and treatment challenges.
  • MicroRNAs (miRNAs) are emerging as crucial cancer biomarkers, offering insights into molecular signatures.
  • miRNAs regulate numerous genes, acting as oncogenes or tumor suppressors, and impacting cellular processes in cancer.

Purpose of the Study:

  • To provide a comprehensive overview of functionally relevant miRNAs in breast cancer.
  • To detail established miRNA target genes and their impact on cellular phenotypes.
  • To discuss the role and application of circulating miRNAs in breast cancer detection and management.

Main Methods:

  • Literature review of studies on miRNA function in breast cancer.
  • Analysis of bioinformatic data on miRNA-gene interactions.
  • Summary of research on circulating miRNAs and their diagnostic potential.

Main Results:

  • miRNAs are integral to breast cancer cell tumorigenesis, metastasis, proliferation, and differentiation.
  • Specific miRNAs have established roles as oncogenes or tumor suppressors.
  • Circulating miRNAs show promise as non-invasive biomarkers for breast cancer detection.

Conclusions:

  • miRNAs are critical players in the hallmarks of breast cancer progression.
  • miRNAs represent a promising avenue for developing novel biomarkers for breast cancer diagnosis.
  • Targeting miRNAs may offer future therapeutic strategies for breast cancer treatment.
Keywords:
biomarkersbreast cancercancer hallmarkscirculating miRNAmicroRNA

More Related Videos

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.9K
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

3.0K

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.8K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.4K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.9K
MicroRNAs01:22

MicroRNAs

12.1K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.2K