Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolutionary Screening of <i>Lacticaseibacillus rhamnosus</i> MP108 for Freeze-Thaw Tolerance.

Microorganisms·2026
Same author

HA thermostability mutations S84F, G167N, and D168N potentiate H9N2 virus transmission in a warming environment.

Emerging microbes & infections·2026
Same author

Rethinking PFAS Behavior in Phosphogypsum Stacks: A Hydrochemically Controlled Multiphase Perspective.

Molecules (Basel, Switzerland)·2026
Same author

Impact of diabetes mellitus on mortality in patients with acute exacerbation of chronic obstructive Pulmonary disease: a meta-analysis and systematic review.

Frontiers in endocrinology·2026
Same author

The PorV protein as a cross-protective antigen against Riemerella anatipestifer infection.

Veterinary microbiology·2026
Same author

Riemerella anatipestifer OMP85, a BamA family outer membrane protein, enhances virulence through recruiting host complement regulator vitronectin to mediate complement evasion.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

Tunable self-assembling cellular microarray for single-neutrophil vital and suicidal extracellular traps.

Lab on a chip·2026
Same journal

Precise programmable tumor cell subpopulation sorting <i>via</i> an electromagnetic microfluidic platform.

Lab on a chip·2026
Same journal

Bridging dimensions: combining one- and two-photon 3D printing for microfluidic device fabrication.

Lab on a chip·2026
Same journal

Microfluidic rare cell analysis beyond counting: workflow design from enrichment to multi-omics.

Lab on a chip·2026
Same journal

A sperm racetrack to separate sperm by swim speed.

Lab on a chip·2026
Same journal

Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.

Lab on a chip·2026
See all related articles

Related Experiment Video

Updated: Apr 18, 2026

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles
11:13

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

Published on: March 13, 2016

11.4K

An on-demand nanofluidic concentrator.

Miao Yu1, Youmin Hou, Hongbo Zhou

  • 1Bioengineering Graduate Program, Biomedical Engineering Division, The Hong Kong University of Science and Technology, Hong Kong, China. meshyao@ust.hk.

Lab on a Chip
|January 30, 2015
PubMed
Summary
This summary is machine-generated.

This study introduces a pressure-assisted nanofluidic concentrator that prevents sample dilution before droplet encapsulation. This novel system enhances biomolecule preconcentration for sensitive detection.

More Related Videos

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
08:20

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

11.0K
Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration
08:43

Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration

Published on: February 1, 2022

3.0K

Related Experiment Videos

Last Updated: Apr 18, 2026

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles
11:13

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

Published on: March 13, 2016

11.4K
Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
08:20

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

11.0K
Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration
08:43

Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration

Published on: February 1, 2022

3.0K

Area of Science:

  • Biomolecular analysis
  • Microfluidics and Nanofluidics
  • Analytical Chemistry

Background:

  • Electrokinetic trapping is efficient for biomolecule preconcentration at nano/microfluidic interfaces.
  • Continuous flow preconcentration methods suffer from diffusion and dispersion, limiting sample preservation.
  • Encapsulating preconcentrated samples in droplets improves stability but requires optimized pre-ejection handling.

Purpose of the Study:

  • To develop a strategy that prevents sample dilution prior to droplet encapsulation in nanofluidic systems.
  • To elucidate the mechanism of sample plug localization using numerical simulations.
  • To create an on-demand nanofluidic concentrator for enhanced biomolecule detection.

Main Methods:

  • Two-dimensional numerical simulations were used to understand pressure-assisted sample plug localization.
  • On-demand nanofluidic concentrators were fabricated using lithography-free nanocracking on polystyrene.
  • An integrated droplet generation module was employed for adaptive sample encapsulation.

Main Results:

  • A pressure-assisted strategy was proposed and validated to position concentrated sample plugs at the ejecting nozzle, minimizing dilution.
  • The system achieved a preconcentration amplification factor of 10^4 for fluorescently labeled bovine serum albumin (BSA).
  • Adjustable parameters (voltage, accumulation time, pulsed pressure) allow for controlled droplet generation with target concentrations.

Conclusions:

  • Assisted pressure plays a crucial role in sample positioning, overcoming limitations of prior preconcentration techniques.
  • The developed on-demand nanofluidic concentrator effectively encapsulates highly concentrated samples, enhancing long-term stability.
  • This approach offers a versatile platform for detecting and analyzing low-abundance biomolecules with improved sensitivity and control.