Related Experiment Video
Updated: Apr 18, 2026

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
Published on: July 15, 2019
Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan
1Department of Intensive Care Medicine, Chi Mei Medical Centre, Tainan City, Taiwan; Department of Medicine, Taipei Medical University, Taipei City, Taiwan.
Abstract:
We first describe two novel variants of blaKPC, blaKPC-16 and blaKPC-17, which were identified in three Klebsiella pneumoniae isolates from a patient in Taiwan. KPC-16 and KPC-17 differed from KPC-2 by two (P202S and F207L) and a single (F207L) amino acid substitutions, respectively. All three isolates with identical pulsotype belonged to sequence type 11. The MICs of the three isolates for colistin and tigecycline were 0.5 μg/mL and 2 μg/mL, respectively. Moreover, an outbreak of at least 39 blaKPC-17-containing K. pneumoniae isolates is ongoing in southern Taiwan in 2014. Physicians should know that blaKPC-17-containing isolates can substantially threaten public health.
Related Concept Videos
Investigation of Disease Outbreaks
Infectious Diseases and Their Occurrence
Single Nucleotide Polymorphisms-SNPs
Steps in Outbreak Investigation

