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Bridging the gap between nature and antioxidant setbacks: delivering caffeic acid to mitochondria
José Teixeira1, Pedro Soares, Sofia Benfeito
1CIQ/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, Porto, 4169-007, Portugal.
None:
As mitochondria have an important role as ATP supplier, cellular ROS producer and apoptosis regulator, these organelles are a promising target for pharmacological intervention in the treatment and management of several diseases. Consequently, research on mitochondria-targeted drugs, which exclude other intracellular structures or extracellular processes, is becoming a hot topic. One approach to address the specific targeting is to conjugate bioactive molecules to a lipophilic cation such as the triphenylphosphonium (TPP(+)). In this chapter, the development of a new antioxidant based on the dietary cinnamic acid-caffeic acid-is described as well as the demonstration of its mitochondriotropic activity.
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