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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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Activin A regulates proliferation, invasion and migration in osteosarcoma cells

Jianwei Zhu1, Fan Liu1, Quanming Wu1

  • 1Department of Orthopedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China.

Molecular Medicine Reports
|January 31, 2015
PubMed
Summary

Activin A, a TGF-β superfamily member, promotes osteosarcoma cell growth and spread. Depleting activin A suppressed these effects, suggesting it is a potential therapeutic target for osteosarcoma.

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