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Updated: Apr 18, 2026

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050
Published on: May 13, 2020
Solid solution hardening of molecular crystals: tautomeric polymorphs of omeprazole
Manish Kumar Mishra1, Upadrasta Ramamurty, Gautam R Desiraju
1Solid State and Structural Chemistry Unit, Indian Institute of Science , Bangalore 560 012, India.
Abstract:
In the context of processing of molecular solids, especially pharmaceuticals, hardness is an important property that often determines the manufacturing steps employed. Through nanoindentation studies on a series of omeprazole polymorphs, in which the proportions of the 5- and 6-methoxy tautomers vary systematically, we demonstrate that solid-solution strengthening can be effectively employed to engineer the hardness of organic solids. High hardness can be attained by increasing lattice resistance to shear sliding of molecular layers during plastic deformation.
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