Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

1.1K
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
1.1K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

2.9K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.9K
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

788
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
788
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

4.4K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
4.4K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

6.3K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
6.3K
Cancer Prevention02:59

Cancer Prevention

8.7K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Promoting contraceptive use among unmarried female migrants in one factory in Shanghai: a pilot workplace intervention.

BMC health services research·2007
Same author

Apoptosis related protein 3, an ATRA-upregulated membrane protein arrests the cell cycle at G1/S phase by decreasing the expression of cyclin D1.

Biochemical and biophysical research communications·2007
Same author

Efficient one-pot synthesis of highly substituted pyridin-2(1H)-ones via the Vilsmeier-Haack reaction of 1-acetyl,1-carbamoyl cyclopropanes.

Organic letters·2007
Same author

Effects of Andrographitis Paniculata extracts on the expression of CD40 in endothelial cells.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban·2007
Same author

Theoretical and experimental investigations on the size of alginate microspheres prepared by dropping and spraying.

Journal of microencapsulation·2007
Same author

Beneficial effects of losartan on vascular injury induced by advanced glycosylation end products and their receptors in spontaneous hypertension rats.

Molecular and cellular biochemistry·2007
Same journal

Nanotechnology-Empowered Photodynamic Therapy for Improved Oral Cancer Treatment.

Anti-cancer agents in medicinal chemistry·2026
Same journal

Design, Synthesis, Spectroscopic Analysis, and In Silico Molecular Docking Study of Novel Azo Compounds as Potential Antioxidant and Anti-Triple-Negative Breast Cancer Agents.

Anti-cancer agents in medicinal chemistry·2026
Same journal

Plant-Derived Polyphenols in the Fight against Colorectal Cancer.

Anti-cancer agents in medicinal chemistry·2026
Same journal

Emerging Frontiers in Nanomedicine for Colorectal Cancer: A Review of Therapeutic Advances, Clinical Evidence, and Patented Technologies.

Anti-cancer agents in medicinal chemistry·2026
Same journal

Microfluidic Synthesis of miR-10a Antisense Oligonucleotides-Loaded LNP Combined with Cisplatin for Colorectal Cancer Therapy.

Anti-cancer agents in medicinal chemistry·2026
Same journal

Synergistic Anticancer Effect of Luteolin and Etoposide via the PI3K/AKT Signaling Pathway.

Anti-cancer agents in medicinal chemistry·2026
See all related articles

Related Experiment Video

Updated: Apr 18, 2026

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
19:44

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

19.3K

Anticancer agents derived from natural cinnamic acids.

Ping Su, Yaling Shi, Jinfeng Wang

  • 1School of Pharmacy, Xi'an Jiaotong University, No. 76, Yanta West Road, 710061, Xi'an, ShaanXi Province, P.R.China. zhj8623@mail.xjtu.edu.cn.

Anti-Cancer Agents in Medicinal Chemistry
|January 31, 2015
PubMed
Summary
This summary is machine-generated.

Cinnamic acid and its derivatives show significant potential as anticancer agents, offering a natural product-based approach for developing new cancer therapies. This review explores their anticancer properties and design strategies.

More Related Videos

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

3.1K
Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
06:00

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Published on: May 14, 2016

11.7K

Related Experiment Videos

Last Updated: Apr 18, 2026

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
19:44

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

19.3K
Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

3.1K
Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
06:00

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Published on: May 14, 2016

11.7K

Area of Science:

  • Natural product chemistry
  • Pharmacology
  • Medicinal chemistry

Background:

  • Cancer remains a leading global cause of mortality.
  • Natural products are a vital source for drug discovery, particularly for anticancer agents.
  • Cinnamic acid and its analogs exhibit promising antiproliferative, antioxidant, antiangiogenic, and antitumorigenic properties.

Purpose of the Study:

  • To review the anticancer potency of cinnamic acid derivatives.
  • To discuss novel strategies for designing effective cinnamic acid-based anticancer agents.
  • To provide insights for researchers developing new cancer therapies.

Main Methods:

  • Literature review of studies on cinnamic acid derivatives and their anticancer activities.
  • Analysis of pharmacological data, including antiproliferative, antioxidant, and antitumorigenic effects.
  • Exploration of structure-activity relationships and design principles for novel derivatives.

Main Results:

  • Cinnamic acid derivatives demonstrate diverse pharmacological activities relevant to cancer treatment.
  • Specific analogs like caffeic acid, sinapic acid, ferulic acid, and isoferulic acid show significant anticancer potential.
  • Optimization of natural product structures can lead to potent anticancer compounds.

Conclusions:

  • Cinnamic acid derivatives represent a promising class of compounds for anticancer drug development.
  • Further research into novel design strategies can enhance their therapeutic efficacy.
  • These natural product-derived compounds offer a valuable avenue for future cancer therapies.