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Single nucleotide polymorphisms on SHIP2 is associated with Type 2 diabetes mellitus in Chinese Han population

Y-M Hao1, Q-J Liu, R-Y Wang

  • 1Department of Endocrinology, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China. lianfu@163.com.

European Review for Medical and Pharmacological Sciences
|January 31, 2015
PubMed
Abstract

Insights

Genetic variations in the SHIP2 gene are linked to type 2 diabetes mellitus (T2DM) and hypertension in the Chinese Han population. Specifically, SHIP2 (+1893CC/AA) showed significant differences, and the SHIP2 (+2945A/G) G allele increased hypertension susceptibility in T2DM patients.

Area of Science:

  • Genetics
  • Endocrinology
  • Metabolic Diseases

Background:

  • Type 2 diabetes mellitus (T2DM) involves insulin resistance and impaired insulin secretion.
  • SHIP2 (Src homology 2-containing 5'-inositol phosphatase 2) negatively regulates insulin signaling.
  • SHIP2 gene polymorphisms have been associated with metabolic syndrome and T2DM in various populations.

Purpose of the Study:

  • To investigate the association between single nucleotide polymorphisms (SNPs) in the SHIP2 gene and the pathogenesis of T2DM in the Chinese Han population.
  • To explore the relationship between SHIP2 SNPs and hypertension in T2DM patients.

Main Methods:

  • Case-control study design.
  • Genotyping of SHIP2 gene single nucleotide polymorphisms (SNPs) in T2DM patients and healthy controls.
  • Statistical analysis of genotype and allele frequencies.

Main Results:

  • Significant differences in genotype and allele frequencies of the SHIP2 (+1893CC/AA) locus were observed between T2DM patients and controls.
  • The G allele of the SHIP2 (+2945A/G) polymorphism was associated with an increased susceptibility to hypertension in T2DM patients.

Conclusions:

  • SHIP2 gene polymorphisms are associated with T2DM pathogenesis in the Chinese Han population.
  • The SHIP2 (+2945A/G) G allele may be a risk factor for hypertension in T2DM patients.

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