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Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Temperature dependence of postmortem MR quantification for soft tissue discrimination.

Wolf-Dieter Zech¹, Nicole Schwendener, Anders Persson

¹From the Institute of Forensic Medicine, University of Bern, Buehlstrasse 20, 3012, Bern, Switzerland, Wolf-Dieter.Zech@irm.unibe.ch.

European Radiology

|February 1, 2015

Summary

This summary is machine-generated.

Postmortem MRI can differentiate thoraco-abdominal organs, but temperature affects T1 values. Correction equations are provided to improve accuracy for computer-aided diagnosis.

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Area of Science:

Medical Imaging
Biophysics
Forensic Science

Background:

Postmortem MRI (magnetic resonance imaging) is crucial for soft tissue characterization.
Accurate quantification is essential for reliable tissue differentiation.
Temperature variations can significantly impact MR signal intensities.

Purpose of the Study:

To investigate and correct temperature-dependent variations in postmortem MR quantification.
To enhance soft tissue characterization and differentiation in thoraco-abdominal organs.
To develop a basis for computer-aided diagnosis in postmortem MRI.

Main Methods:

Acquired 3-T MRI scans from 35 postmortem subjects.
Quantified T1, T2, and proton density (PD) values in liver, spleen, myocardium, muscle, and fat.
Measured core body temperature and correlated it with MR quantitative values.

Main Results:

Postmortem MRI successfully differentiated various thoraco-abdominal organs.
Quantitative MR values, particularly T1, showed significant temperature dependence.
Temperature correction to 37°C improved tissue discrimination.

Conclusions:

Postmortem MRI is feasible for soft tissue discrimination and characterization.
Temperature dependence of T1 values presents a challenge for MR quantification.
Provided correction equations enhance accuracy and enable computer-aided diagnosis, potentially applicable to living patients.