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ADAMTS proteases and cancer.

Santiago Cal1, Carlos López-Otín1

  • 1Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología del Principado de Asturias, IUOPA, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain.

Matrix Biology : Journal of the International Society for Matrix Biology
|February 1, 2015
PubMed
Summary

A disintegrin and metalloprotease domains with thrombospondins motifs (ADAMTSs) are extracellular proteases with dual roles in cancer. Their functions in the tumor microenvironment, influencing cell behavior and cancer progression, require further mechanistic study.

Keywords:
DisintegrinMetalloproteaseThrombospondinTumor microenvironmentTumorigenesis

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