Related Experiment Video
Updated: Apr 18, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Anti-diabetic molecules from Cycas pectinata Griff. traditionally used by the Maiba-Maibi
S Laishram1, Y Sheikh1, D S Moirangthem1
1Natural Product Chemistry & Pharmacology Programme, Institute of Bioresources & Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
Abstract:
Bioactivity guided chemical investigation on active anti-diabetic constituents of the fruits of Cycas pectinata Griff. (FCP) characterized EAFr-5 as the most potent sub fraction which significantly reduced the blood glucose level to normal in STZ induced diabetic rats. It was shown to contain the biflavonoids amentoflavone (1) and 2,3-dihydroamentoflavone (2) which exhibited significantly high inhibitory potency against α-glucosidase (IC50 8.09 ± 0.023 and 9.77 ± 0.032 μM, respectively) and α-amylase (IC50 73.6 ± 0.48 and 39.69 ± 0.39 μM, respectively). This is the first report of bioactivity guided isolation of anti-diabetic constituents from the traditionally used fruits of Cycas pectinata Griff.
Related Concept Videos
Dipeptidyl Peptidase 4 Inhibitors
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Cellulose and Pectic Polysaccharides
As a cell matures, its cell wall specializes according to its type. For example, the...
Oral Hypoglycemic Agents: Glinides
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
Insulin and C-peptide are...
