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Updated: Apr 18, 2026

Taking Advantage of Reduced Droplet-surface Interaction to Optimize Transport of Bioanalytes in Digital Microfluidics

Taking Advantage of Reduced Droplet-surface Interaction to Optimize Transport of Bioanalytes in Digital Microfluidics

Published on: November 10, 2014

Automatic droplet transportation on a plastic microfluidic device having wettability gradient surface.

Y Nakashima¹, Y Nakanishi¹, T Yasuda²

¹Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 096-8555, Japan.

The Review of Scientific Instruments

|February 2, 2015

Summary

This study demonstrates a novel microfluidic device for automatic droplet transport on a plastic plate. The device utilizes a wettability gradient surface to control liquid movement without external power.

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Area of Science:

Materials Science
Microfluidics
Surface Chemistry

Background:

Droplet manipulation is crucial for microfluidic applications.
Controlling droplet movement often requires complex external forces or systems.
Developing passive droplet transport methods is an ongoing research area.

Purpose of the Study:

To present a microfluidic device capable of automatic droplet transportation.
To investigate the use of wettability gradient surfaces for droplet movement.
To demonstrate droplet transport in both open and enclosed microchannels.

Main Methods:

Fabrication of a Cyclo Olefin Polymer (COP) plate with a SiO2 membrane.
Creation of a wettability gradient surface using lithographic patterning of hydrophilic SiO2 on hydrophobic COP.
Generation of wedge-shaped hydrophobic and hydrophilic patterns to induce a surface tension gradient.
Testing droplet transportation with 5 μl of water on the gradient surface and within an enclosed microchannel.

Main Results:

Successful automatic transportation of a 5 μl water droplet along the SiO2/COP wettability gradient pattern.
Demonstration of droplet transport within an enclosed microchannel, preventing evaporation.
Achieved passive droplet movement driven by surface tension imbalances.

Conclusions:

The developed microfluidic device effectively achieves automatic droplet transportation using a wettability gradient.
The wettability gradient surface on a COP plate with SiO2 patterns is a viable method for passive droplet control.
The enclosed microchannel design prevents evaporation, enabling controlled droplet transport in a closed system.