Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

1.4K
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
1.4K
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

1.7K
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
1.7K
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

1.1K
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
1.1K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

882
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
882
Teratogenicity01:07

Teratogenicity

4.6K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The ethics of a work strike.

The Medical journal of Malaysia·2022
Same author

Applications of Hairpin DNA-Functionalized Gold Nanoparticles for Imaging mRNA in Living Cells.

Methods in enzymology·2016
Same author

Oesophageal intubation and ventilation as initial airway support of newborn infant with tracheal agenesis.

The Medical journal of Malaysia·2014
Same author

Interrupted aortic arch and aortopulmonary window demonstrated on 64-slice multidetector computed tomography angiography.

BMJ case reports·2011
Same author

Patient-initiated mandatory boluses for ambulatory continuous interscalene analgesia: an effective strategy for optimizing analgesia and minimizing side-effects.

British journal of anaesthesia·2010
Same author

Risk factors associated with chronic lung disease in Malaysian very low birthweight infants.

The Medical journal of Malaysia·2007
Same journal

Diagnostic performance of computed tomography colonography following incomplete colonoscopy and its associated factors: A single-centre retrospective study.

The Medical journal of Malaysia·2026
Same journal

Gender representation across surgical specialties in Malaysia.

The Medical journal of Malaysia·2026
Same journal

Non-specific orbital inflammation: Clinical and histopathological insights from a 6-year single-centre Malaysian cohort.

The Medical journal of Malaysia·2026
Same journal

Prevalence of metabolic associated fatty liver disease (MAFLD) and its associated factors among type 2 diabetes mellitus (T2DM) in primary care settings in Kuantan, Pahang.

The Medical journal of Malaysia·2026
Same journal

Sixteen years of cochlear implant surgery in cochleovestibular malformation and cochlear nerve deficiency: Insights from northern Malaysia.

The Medical journal of Malaysia·2026
Same journal

Evaluation of vision-related quality of life and its associated factors in patients with diabetic vitreoretinal disease post trans pars plana vitrectomy using visual functioning questionnaire-25.

The Medical journal of Malaysia·2026
See all related articles

Related Experiment Video

Updated: Apr 18, 2026

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

2.8K

Neonatal bartter syndrome.

A C Wong1, L G Chan2

  • 1Sarawak General Hospital, Paediatric Department, Jalan Hospital, 93586, Kuching, Sarawak, Malaysia. anncheng@hotmail.com.

The Medical Journal of Malaysia
|February 2, 2015
PubMed
Summary
This summary is machine-generated.

Neonatal Bartter syndrome is a rare kidney disorder. Early E. coli sepsis and dehydration in a premature infant masked its typical biochemical signs, complicating diagnosis.

More Related Videos

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates
06:10

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

2.6K
Development of a Neonatal Rat Model for Brachial Plexus Birth Injury
09:42

Development of a Neonatal Rat Model for Brachial Plexus Birth Injury

Published on: March 27, 2026

243

Related Experiment Videos

Last Updated: Apr 18, 2026

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

2.8K
Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates
06:10

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

2.6K
Development of a Neonatal Rat Model for Brachial Plexus Birth Injury
09:42

Development of a Neonatal Rat Model for Brachial Plexus Birth Injury

Published on: March 27, 2026

243

Area of Science:

  • Pediatrics
  • Neonatology
  • Nephrology

Background:

  • Neonatal Bartter syndrome is a rare genetic disorder affecting kidney tubules.
  • Premature infants are susceptible to various complications, including infections and dehydration.
  • Antenatal polyhydramnios can be an indicator of fetal kidney or urinary tract abnormalities.

Purpose of the Study:

  • To report a case of neonatal Bartter syndrome in a premature infant.
  • To highlight diagnostic challenges posed by concurrent severe illness.
  • To emphasize the importance of considering rare genetic disorders in complex neonatal cases.

Main Methods:

  • Case report of a preterm infant (31 weeks gestation).
  • Clinical presentation including antenatal polyhydramnios and amnioreduction.
  • Management of early-onset E. coli sepsis and severe dehydration.
  • Monitoring of renal function and electrolytes.

Main Results:

  • The infant presented with severe dehydration and pre-renal renal impairment.
  • The concurrent sepsis and dehydration obscured the characteristic hypokalemic, hypochloremic metabolic alkalosis of Bartter syndrome.
  • Diagnosis of neonatal Bartter syndrome was challenging due to atypical presentation.

Conclusions:

  • Severe illness, such as sepsis and dehydration, can mask the typical biochemical findings of neonatal Bartter syndrome.
  • Diagnostic vigilance is crucial in premature neonates with unexplained complications.
  • Prompt recognition and management of underlying conditions are vital for improved outcomes in neonates with complex presentations.