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Nitroimidazole derivatives: a patent review of US 2014/0141084 A1
1State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210093 , PR, China . +86 25 8359 2672 ; +86 25 8359 2672 ; zhuhl@nju.edu.cn ; pclv@nju.edu.cn.
Abstract:
Nitroimidazoles and their derivatives have drawn continuing interest over the years because of their varied biological activities and their recently found applications in drug development for antimicrobial chemotherapeutics and antiangiogenic hypoxic cell radiosensitizers. The electron-deficient nitroaromatic compounds have been investigated for use in cancer treatment as chemical modifiers. In this patent (US 2014/0141084 A1), amphiphilic polymers were designed and prepared based on nitroimidazole derivatives and carboxymethyl dextran, which can be used for the hypoxia-selective release of diagnostics or drugs.
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