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A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
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A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice

Published on: April 17, 2019

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SPECT- and PET-based patient-tailored treatment in neuroendocrine tumors: a comprehensive multidisciplinary team

R A Werner1, Christina Bluemel, M Lassmann

  • 1From the Departments of *Nuclear Medicine, and †Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany; ‡Department of Nuclear Medicine, Humanitas Research Hospital, Rozzano, Milan, Italy; §Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA; ║Department of Radiology, University of Southern California Keck School of Medicine, Los Angeles, CA; ¶Department of Nuclear Medicine, Santa Maria della Misericordia Hospital, Rovigo; and **Department of Endocrinology, University of School of Ferrara, Ferrara, Italy.

Clinical Nuclear Medicine
|February 3, 2015
PubMed

Insights

Targeted radiolabeled compounds exploit somatostatin receptors on neuroendocrine tumors (NETs) for diagnosis and therapy. This theranostic approach enhances treatment tailoring and visualization of target expression.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiopharmaceutical Therapy

Background:

  • Neuroendocrine tumors (NETs) often overexpress somatostatin receptors on their cell surface.
  • Multimodal functional imaging (SPECT, PET) can detect this overexpression.
  • This presents a therapeutic target for radiolabeled compounds.

Purpose of the Study:

  • To introduce the theranostic concept in the context of NETs.
  • To discuss diagnostic imaging tracers (SPECT, PET) for target visualization.
  • To review peptide receptor radionuclide therapy (PRRT) principles and future directions.

Main Methods:

  • Review of theranostic principles in NETs.
  • Analysis of available SPECT and PET tracers for somatostatin receptor imaging.
  • Discussion of current PRRT and emerging concepts.

Main Results:

  • Somatostatin receptor-targeted theranostics offer a viable treatment option for NETs.
  • SPECT and PET tracers aid in diagnostic imaging and treatment selection.
  • PRRT principles are established, with ongoing development of new approaches.

Conclusions:

  • Theranostics, leveraging somatostatin receptor targeting, are crucial for NET management.
  • Advanced imaging and radionuclide therapies are transforming NET treatment.
  • Future innovations will likely further refine theranostic strategies for NETs.

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