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Lithium use from 2000 to 2010 in Italy: a population-based study.

A Parabiaghi1, A Barbato1, P Risso1

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Pharmacopsychiatry
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Summary
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Lithium use for bipolar disorder fluctuated between 2000-2010, with treatment prevalence increasing 38%. Prescribing patterns shifted temporarily, impacting lithium and other mood stabilizer use.

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Area of Science:

  • Pharmacological treatments
  • Bipolar disorder management
  • Drug utilization studies

Background:

  • Lithium is a primary, evidence-based treatment for bipolar disorder.
  • Understanding lithium's utilization patterns is crucial for effective mental health management.

Purpose of the Study:

  • To determine the prevalence and incidence of lithium use in Italy from 2000 to 2010.
  • To analyze prescribing trends of other mood stabilizers among lithium users.

Main Methods:

  • Utilized regional administrative dispensing data from 2000-2010.
  • Defined lithium users as those with at least one annual dispensation.
  • Defined lithium-treated individuals as those with over four annual dispensations.

Main Results:

  • Lithium utilization rates remained stable, but prescribed amounts increased due to longer treatment durations and higher doses.
  • Prevalence of lithium use varied, with an initial rise, then a decline, followed by a subsequent increase.
  • The prevalence of lithium treatment significantly grew by 38% over the study period.

Conclusions:

  • Observed fluctuations in lithium use correlate with changes in new prescriptions.
  • Shifts in prescribing attitudes towards lithium and other mood stabilizers were temporary.
  • Reconsideration of prescribing practices influenced lithium and alternative mood stabilizer utilization.