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Updated: Apr 18, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
Is Notch Signaling a Specific Target in Hepatocellular Carcinoma?
Lichun Sun1, Guangchun Sun, Yan Yu
1Department of Pharmacy, The Fifth People's Hospital of Shanghai, Fudan University; 801 He-Qing Rd., Shanghai 200240, China. lsun@tulane.edu.
Abstract:
Hepatocellular carcinoma (HCC) is one of the most malignant cancers, with the second highest cancer death rate world-wide, next to lung cancer. The signaling mechanisms in HCC are currently not clear. Notch signaling, which is highly conserved and plays a critical role in many cancers, was found to be aberrantly upregulated in HCC tissues compared to normal liver tissues. Accumulating evidence supports that Notch signaling plays a significantly important role in HCC carcinogenesis. This review discusses the functions of Notch signaling in HCC and its potential therapeutic applications against this cancer.
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