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A new turn on Pd(2+)-specific fluorescence probe and its use as an imaging reagent for cellular uptake in Hct116
Upendar Reddy G1, Firoj Ali, Nandaraj Taye
1Organic Chemistry Division, CSIR-National Chemical Laboratory, Pune-411008, India. a.das@ncl.res.in.
Abstract:
A new coumarin-rhodamine conjugate is used as a specific probe for Pd(2+) ions and this could even delineate Pd(II) from Pd(0) or Pd(IV) in aqueous buffer medium (pH ∼ 7). Laser confocal microscopic studies reveal that efficient cellular internalization of this reagent helps in imaging the cellular uptake of Pd(2+) as low as 0.1 ppm in Hct 116 cells. This reagent could even be used for estimation of Pd(2+) in human urine samples.
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