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Methods for Detecting Cough and Airway Inflammation in Mice
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Neurogenic cough.

Kenneth W Altman1, J Pieter Noordzij2, Clark A Rosen3

  • 1Department of Otolaryngology-Head & Neck Surgery, Baylor College of Medicine, Houston, Texas.

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|February 4, 2015
PubMed
Summary
This summary is machine-generated.

Neurogenic cough, often caused by sensory neuropathy, is challenging to diagnose. Effective treatments include amitriptyline, gabapentin, pregabalin, baclofen, and botulinum toxin for this refractory cough condition.

Keywords:
Coughlaryngeal neuropathyneurogenic coughparesisvagus

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Area of Science:

  • Neurology
  • Otolaryngology
  • Pulmonology

Background:

  • Neurogenic cough is a complex condition often linked to sensory neuropathy.
  • Idiopathic sensory neuropathy is a common cause of this persistent cough.

Purpose of the Study:

  • To review current understanding of neurogenic cough pathophysiology.
  • To outline diagnostic challenges and treatment options for neurogenic cough.

Main Methods:

  • Literature review of scientific publications on neurogenic cough.
  • Analysis of diagnostic methods including laryngoscopy and laryngeal electromyography.
  • Evaluation of pharmacologic treatments based on clinical trials and case reports.

Main Results:

  • Neurogenic cough diagnosis is often made by exclusion due to its sensory nature.
  • Laryngeal examination can indicate underlying sensory neuropathy.
  • Amitriptyline and gabapentin show proven efficacy; pregabalin, baclofen, and botulinum toxin are also suggested.

Conclusions:

  • Sensory neuropathy is a significant factor in chronic refractory cough.
  • Pharmacologic interventions offer viable treatment strategies for neurogenic cough.