Related Experiment Video
Updated: Apr 17, 2026

Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
Neurogenic cough
Kenneth W Altman1, J Pieter Noordzij2, Clark A Rosen3
1Department of Otolaryngology-Head & Neck Surgery, Baylor College of Medicine, Houston, Texas.
Abstract:
We review contemporary concepts of the pathophysiology of neurogenic cough, and its evaluation and treatment based on scientific publications addressing neurogenic cough. Neurogenic cough is thought to be the result of sensory neuropathy, most commonly idiopathic. Because it is principally a sensory phenomenon, clinical evaluation is challenging, the diagnosis most often being made by exclusion. Identification of motor paresis, either by laryngoscopy or laryngeal electromyography, may suggest the presence of sensory neuropathy. The utility of amitriptyline and gabapentin has been demonstrated in randomized clinical trials, and retrospective series and case reports have suggested efficacy of pregabalin, baclofen, and botulinum toxin. Sensory neuropathy appears to be an important cause of chronic refractory cough, and appears amenable to treatment with a variety of pharmacologic agents.
Related Concept Videos
Physiology of Respiration II: Neurogenic Control of Respiration
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
Gross Anatomy of the Lungs
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Myasthenia Gravis ll: Pathophysiology
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

