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Harmful Effects of Synthetic Surface-Active Detergents against Atopic Dermatitis
Hajime Deguchi1, Riho Aoyama1, Hideaki Takahashi1
1Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan ; Department of Pathology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
Abstract:
We report herein two cases of intractable atopic dermatitis successfully treated by simply avoiding the contact with surface-active detergents in the daily life and living. The detergents were closely related to the exacerbation and remission of the disease. Steroid ointment was no longer used. We discuss that the removal of horny layer lipids by surface-active detergents accelerates the transepidermal water loss and disturbs the barrier function of the epidermis and thus is intimately involved in the pathogenesis of atopic dermatitis.
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