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Circulating microRNAs in response to exercise
1Regeneration and Ageing Lab and Experimental Center of Life Sciences, School of Life Science, Shanghai University, Shanghai, China; Shanghai Key Laboratory of Bio-Energy Crops, School of Life Science, Shanghai, China.
Scandinavian Journal of Medicine & Science in Sports
|February 5, 2015
Summary
Circulating microRNAs (miRNAs) are stable molecules released into the blood. Exercise influences these miRNAs, offering potential therapeutic targets for improving exercise capacity in various diseases.
Area of Science:
- Molecular Biology
- Exercise Physiology
- Biochemistry
Background:
- MicroRNAs (miRNAs) are endogenous noncoding RNAs regulating gene expression post-transcriptionally.
- miRNAs are crucial in biological processes like proliferation, differentiation, and metabolism.
- Circulating miRNAs are stable and detectable in bodily fluids.
Purpose of the Study:
- To review and summarize recent findings on circulating miRNAs in response to exercise.
- To discuss the role of circulating miRNAs in exercise-induced adaptations.
- To explore the potential of circulating miRNAs as therapeutic targets.
Main Methods:
- Literature review of studies investigating circulating miRNAs and exercise.
- Analysis of data on miRNA expression changes following acute and chronic exercise.
- Synthesis of current knowledge on miRNA regulation in exercise physiology.
Main Results:
- Exercise, both acute and chronic, significantly impacts circulating miRNA profiles.
- Specific circulating miRNAs show altered expression levels in response to different exercise stimuli.
- These changes suggest miRNAs are involved in the physiological adaptations to exercise.
Conclusions:
- Circulating miRNAs are responsive to exercise and reflect physiological adaptations.
- Understanding these responses can lead to novel biomarkers for exercise capacity.
- Targeting circulating miRNAs may offer therapeutic strategies for conditions like heart failure.
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