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Related Concept Videos

Genomics02:02

Genomics

42.0K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Next-generation Sequencing03:00

Next-generation Sequencing

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
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RNA-seq03:21

RNA-seq

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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Protein Networks02:26

Protein Networks

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

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Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
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Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Related Experiment Video

Updated: Apr 17, 2026

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
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Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

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Next-generation technologies for multiomics approaches including interactome sequencing.

Hiroyuki Ohashi1, Mai Hasegawa2, Kentaro Wakimoto2

  • 1Division of Interactome Medical Sciences, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

Biomed Research International
|February 5, 2015
PubMed
Summary
This summary is machine-generated.

High-throughput omics research, including genomics and proteomics, is advancing biosciences. Innovative techniques enable low-cost, high-speed analysis for future medical breakthroughs.

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Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
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High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq
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Area of Science:

  • Biotechnology and Bioinformatics
  • Genomics and Proteomics
  • Molecular Biology

Background:

  • High-speed analytical techniques like next-generation sequencing and microarrays have revolutionized biological data analysis.
  • These advancements facilitate high-throughput analysis of biological information at reduced costs, driving progress in medical and bioscience fields.

Purpose of the Study:

  • To review innovative techniques for omics research.
  • To discuss the applications of these methods in genomics, transcriptomics, metabolomics, proteomics, and interactomics.
  • To highlight the potential of novel technologies, such as interactome sequencing, in future life science research.

Main Methods:

  • Review of current high-throughput analytical techniques.
  • Discussion of applications in various omics disciplines.
  • Introduction of a novel interactome sequencing technology.

Main Results:

  • Identification of key innovative techniques for omics research.
  • Exploration of the broad applicability of these methods across different omics fields.
  • Presentation of a new interactome sequencing technology with potential future applications.

Conclusions:

  • Innovative high-throughput techniques are crucial for advancing omics research.
  • These methods offer new avenues for discovery in medical and life sciences.
  • The developed interactome sequencing technology shows promise for future research applications.