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Updated: Apr 17, 2026

In Vivo Protocol of Controlled Subconcussive Head Impacts for the Validation of Field Study Data
Published on: April 18, 2019
Sub-concussive hit characteristics predict deviant brain metabolism in football athletes
Victoria N Poole1, Evan L Breedlove, Trey E Shenk
1a Weldon School of Biomedical Engineering , Purdue University , West Lafayette , Indiana.
Abstract:
Magnetic resonance spectroscopy and helmet telemetry were used to monitor the neural metabolic response to repetitive head collisions in 25 high school American football athletes. Specific hit characteristics were determined highly predictive of metabolic alterations, suggesting that sub-concussive blows can produce biochemical changes and potentially lead to neurological problems.
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