Nickel-catalyzed selective oxidative radical cross-coupling: an effective strategy for inert Csp3-H functionalization
Dong Liu1, Yuxiu Li, Xiaotian Qi
1College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, PR China.
Abstract:
An effective strategy for inert Csp(3)-H functionalization through nickel-catalyzed selective radical cross-couplings was demonstrated. Density functional theory calculations were conducted and strongly supported the radical cross-coupling pathway assisted by nickel catalyst, which was further confirmed by radical-trapping experiments. Different arylborates including arylboronic acids, arylboronic acid esters and 2,4,6-triarylboroxin were all good coupling partners, generating the corresponding Csp(3)-H arylation products in good yields.
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