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Related Experiment Video

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The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

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Symptomatic factor XIII deficiency with normal urea solubility test.

Michael J Sanfelippo, Joseph J Mazza, Richard J Mercier

Clinical Laboratory

|February 6, 2015

Summary

This summary is machine-generated.

Factor XIII deficiency, a bleeding disorder, can be missed by the urea solubility test. A sensitive assay is crucial for diagnosing this condition, especially after surgery.

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Area of Science:

Hematology
Clinical Diagnostics
Bleeding Disorders

Background:

Factor XIII deficiency is a rare bleeding disorder.
Traditionally diagnosed using the urea solubility test.
This method has limitations in sensitivity.

Observation:

A patient presented with delayed post-surgical bleeding.
Standard screening tests, including the urea solubility test, were normal.
This indicated a potential diagnostic challenge.

Findings:

Factor XIII deficiency was confirmed using an automated assay measuring factor XIII antigen levels.
The patient responded well to cryoprecipitate treatment.
This highlights limitations of the urea solubility test.

Implications:

Patients with unexplained bleeding and normal screening tests require sensitive factor XIII testing.
The urea solubility test lacks sensitivity and should be reconsidered.
Accurate diagnosis and treatment of factor XIII deficiency are essential for patient outcomes.