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Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
Published on: October 22, 2014
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Transradial catheterization may decrease the radial artery luminal diameter and impair the vasodilatation response in
Ali Buturak1, Burak Murat Tekturk2, Aleks Degirmencioglu3
1Department of Cardiology, Acibadem University School of Medicine, Kerem Aydinlar Kampusu, Icerenkoy Mah. Kayisdagi Cad. No: 32, Ataşehir, Istanbul, Turkey. alibuturak@yahoo.com.
Heart and Vessels
|February 6, 2015
Summary
Transradial catheterization (TRC) can cause long-term reduction in radial artery diameter and impaired vasodilatation. These vascular changes, including reduced flow-mediated and nitroglycerin-mediated dilatation, may persist six months post-procedure.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Vascular Biology
Background:
- Transradial catheterization (TRC) is a common procedure for cardiac interventions.
- Potential long-term vascular changes in the radial artery following TRC are not fully understood.
- Existing data on the persistence or repair of TRC-induced vascular impairment is controversial.
Purpose of the Study:
- To evaluate late-term changes in radial artery luminal diameter (RAD) and vasodilatation response after TRC.
- To investigate whether anatomical and functional impairments of the radial artery persist or resolve six months post-TRC.
Main Methods:
- Prospective study of 56 patients undergoing TRC.
- High-resolution ultrasound was used to measure baseline RAD, flow-mediated dilatation (FMD), and nitroglycerin-mediated dilatation (NMD) before TRC.
- RAD, FMD, and NMD were reassessed at the same radial artery access site six months after TRC.
Main Results:
- A significant reduction in RAD was observed six months post-TRC (2.85 ± 0.44 mm vs. 2.74 ± 0.42 mm, p = 0.0001).
- Both FMD (9.45 ± 5.01% vs. 5.66 ± 5.87%, p = 0.0001) and NMD (9.52 ± 6.77% vs. 6.64 ± 6.51%, p = 0.018) were significantly reduced at six months.
- A higher pre-procedural radial artery diameter to sheath size ratio was an independent predictor of NMD reduction (p = 0.024).
Conclusions:
- TRC can lead to significant long-term reduction in radial artery luminal diameter.
- The vasodilatation response of the radial artery is impaired at late term following TRC.
- Vascular impairment may persist six months after transradial catheterization, highlighting the need for further investigation into management and prevention strategies.
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