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Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
Published on: February 16, 2020
[The early warning and prognostic value of serum soluble TREM-1 for active pulmonary tuberculosis]
Jincheng Zeng1, Bin Kong2, Wenyu Xiang2
1Institute of Laboratory Medicine, Guangdong Medical College, Dongguan 523808; Guangdong Provincial Key Laboratory for Medical Molecular Diagnostics, Dongguan 523808, China.
Objective:
To investigate the role of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in patients with active pulmonary tuberculosis (ATB) and explore its clinical significance.
Methods:
The study included 78 cases of ATB patients and 40 cases of healthy volunteers from Dongguan Hospital for Chronic Diseases. Peripheral blood neutrophils and monocytes were counted by automated hematology analyzer. Serum sTREM-1 levels were detected by ELISA, and then the relevance with neutrophils and monocytes were analyzed by Pearson correlation test, respectively.
Results:
The absolute numbers of neutrophils and monocytes, and the levels of serum sTREM-1 were higher in ATB patients than those in normal controls. In smear positive patients, the absolute numbers of neutrophils and monocytes, and the levels of serum sTREM-1 were higher than those in smear negative patients. The absolute numbers of neutrophils and monocytes, and the levels of serum sTREM-1 decreased in ATB patients after anti-TB drug treatments. Serum sTREM-1 level ≥ 528.14 pg/mL was very useful to diagnosis the smear positive ATB, and the accuracy was 100%. Pearson correlation test revealed that the absolute numbers of neutrophils and monocytes were both positively correlated to the levels of serum sTREM-1.
Conclusion:
High serum levels of sTREM-1 may be of high value for early warning and prediction of poor prognosis in ATB patients.
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