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Emperipolesis - a review

Varun Rastogi1, Rachna Sharma2, Satya Ranjan Misra3

  • 1Reader, Department of Oral & Maxillofacial Pathology, Kalka Dental College , Meerut, Uttar Pradesh, India .

Journal of Clinical and Diagnostic Research : JCDR
|February 6, 2015
PubMed

Insights

Emperipolesis is a rare biological process where one cell penetrates another, remaining viable. This process can be normal or indicate diseases like Hodgkin

Area of Science:

  • Cell Biology
  • Pathology

Background:

  • Emperipolesis involves a cell penetrating another living cell, differing from phagocytosis.
  • The engulfed cell remains viable and can exit without damage.

Purpose of the Study:

  • To review the rare biological process of emperipolesis.
  • To highlight its physiological and pathological roles.

Main Methods:

  • Literature review of emperipolesis.
  • Analysis of its occurrence in normal and pathological conditions.

Main Results:

  • Emperipolesis is an uncommon process observed in both normal and pathological states.
  • Histiocytes and megakaryocytes are involved in normal emperipolesis.
  • Tumor giant cells in Hodgkin's disease and Rosai-Dorfman disease exemplify pathological emperipolesis.

Conclusions:

  • Emperipolesis is a rare phenomenon with significant implications in certain diseases.
  • Further research is needed due to limited literature on this process.
Keywords:
Giant cellsMacrophageUncommon biologic process

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