Related Experiment Video
Updated: Apr 17, 2026

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
Published on: August 3, 2021
Ubiquitous assembly of amphiphilic baskets into unilamellar vesicles and their recognition characteristics
Yian Ruan1, Shigui Chen, Jason D Brown
1Department of Chemistry and Biochemistry, The Ohio State University , 100 West 18th Avenue, Columbus, Ohio 43210, United States.
Abstract:
An amphiphilic basket of type 1 (339 Å(3)) has been found to assemble into unilamellar vesicles in water. The assembled host encapsulates organophosphonates (OPs) (119-185 A(3)) with a particularly high affinity (Ka ∼ 10(5) M(-1)) toward dimethyl phenylphosphonate (185 Å(3)) whose size and shape resemble that of soman (186 Å(3)). Importantly, the entrapment of OPs prompts a phase transformation of vesicular 1 into nanoparticles or larger vesicles as a function of the shape of the host-guest complex.
Related Concept Videos
Micelles
Assembly of the Lipid Bilayer in the ER
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
Mechanisms of Membrane Domain Formation
Another mechanism for membrane domain formation involves membrane proteins interacting with...
Clathrin Coated Vesicles
Pinching-off of Coated Vesicles
Intralumenal Vesicles and Multivesicular Bodies

