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Related Experiment Video

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Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

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Disrupted resting-state functional connectivity in progressive supranuclear palsy.

M C Piattella¹, F Tona², M Bologna³

¹From the Department of Neurology and Psychiatry (M.C.P., F.T., E.S., A.F., N.P., A.B., P.P.), Sapienza, University of Rome, Italy mcpiattella@gmail.com.

AJNR. American Journal of Neuroradiology

|February 7, 2015

Summary

This study reveals widespread functional connectivity deficits in progressive supranuclear palsy (PSP) patients, impacting both motor and cognitive functions. These disruptions in brain networks are linked to disease severity and specific symptom domains in PSP.

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Area of Science:

Neuroscience
Neurology
Radiology

Background:

Previous studies on progressive supranuclear palsy (PSP) functional connectivity focused on the thalamus and midbrain.
Subcortical structure abnormalities are implicated in PSP's motor and cognitive decline.

Purpose of the Study:

To investigate functional connectivity abnormalities in subcortical structures in PSP patients.
To correlate these functional connectivity changes with motor and non-motor symptoms.

Main Methods:

Nineteen PSP patients and 12 healthy controls underwent resting-state fMRI, 3D T1-weighted imaging, and DTI.
fMRI data analysis utilized seed regions including the dorsal midbrain, thalamus, caudate nucleus, putamen, and pallidum.

Main Results:

PSP patients exhibited reduced functional connectivity across all 5 resting-state networks compared to controls.
Decreased connectivity in the thalamus and pallidum correlated with clinical assessments (Hoehn and Yahr, PSPRS, MMSE).
Subcortical atrophy and DTI abnormalities were observed in PSP patients.

Conclusions:

Progressive supranuclear palsy is characterized by widespread cortical-subcortical connectivity disruption.
These findings offer insights into the pathophysiology of motor and cognitive impairments in PSP.