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MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
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Prefrontal glucose metabolism in medication-resistant major depression

Cheng-Ta Li1, Tung-Ping Su1, Shyh-Jen Wang1

  • 1Cheng-Ta Li, MD, PhD, Tung-Ping Su, MD, Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Institute of Brain Science, and Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei; Shyh-Jen Wang, MD, Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei; Pei-Chi Tu, MD, PhD, Department of Psychiatry, Taipei Veterans General Hospital, and Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei; Jen-Chuen Hsieh, MD, PhD, Institute of Brain Science, National Yang-Ming University, Taipei, Integrated Brain Research Unit, Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, and Centre of Neuropsychiatric Research, National Health and Research Institute, ChuNan, Taiwan.

The British Journal of Psychiatry : the Journal of Mental Science
|February 7, 2015
PubMed
Summary

Medication-resistant depression (MRD) is linked to impaired prefrontal cortex function and attention deficits. This study found reduced glucose metabolism in the prefrontal cortex of MRD patients, suggesting hypofrontality plays a key role.

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