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Updated: Apr 17, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Pyoderma gangrenosum: a commonly overlooked ulcerative condition.

Daniel Zunsheng Tay¹, Ki-Wei Tan², Yong-Kwang Tay³

¹Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228.

Journal of Family Medicine and Primary Care

|February 7, 2015

Summary

This summary is machine-generated.

Pyoderma gangrenosum (PG) treatment with systemic corticosteroids and immunosuppressants led to complete healing in all patients within 1-3 months. Early dermatology referral is crucial for rapidly progressing ulcers unresponsive to standard wound care.

Keywords:

Bluish edge painful pyoderma gangrenosum rapid progression ulcer

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Last Updated: Apr 17, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

Dermatology
Immunology
Inflammatory Diseases

Background:

Pyoderma gangrenosum (PG) is a rare, destructive neutrophilic dermatosis.
PG often mimics other ulcerative skin conditions, complicating diagnosis.

Purpose of the Study:

To evaluate patient demographics, clinical presentation, histopathology, associated conditions, and treatment outcomes for Pyoderma gangrenosum.
To assess the efficacy of treatment regimens and recurrence rates in PG patients.

Main Methods:

Retrospective study of five patients diagnosed with PG between 2010 and 2013.
Evaluation of clinical data including lesion characteristics, histopathology, comorbidities, and treatment protocols.

Main Results:

All five patients (3 male, 2 female; age 19-58) presented with ulcerative lesions, primarily on lower limbs.
Systemic diseases, including inflammatory bowel disease and autoimmune conditions, were present in all patients.
Complete healing was achieved in all cases within 1-3 months using systemic corticosteroids +/- immunosuppressants; no recurrence was reported.

Conclusions:

Systemic corticosteroids, often with steroid-sparing agents, are the primary treatment for Pyoderma gangrenosum.
Prompt dermatological consultation is recommended for non-healing ulcers to ensure timely diagnosis and management of PG.