Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

5.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
5.0K
Adult Stem Cells01:33

Adult Stem Cells

34.5K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
34.5K
Stem Cell Culture01:17

Stem Cell Culture

6.7K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.7K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

4.2K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
4.2K
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

6.9K
Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
6.9K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.5K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Chimeric Airway Model Enables Evaluation of Essential Genes In Vivo.

American journal of respiratory cell and molecular biology·2026
Same author

Impact of migalastat therapy on corneal deposits in a female with Fabry disease: A case report.

Molecular genetics and metabolism reports·2026
Same author

CFTR facilitates fluid secretion by ferret alveolar type 2 cells.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026
Same author

Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell renewal in idiopathic pulmonary fibrosis.

The Journal of clinical investigation·2026
Same author

Syndecan-1 Promotes Alveolar Type 2 Epithelial Cell Senescence during Lung Fibrosis.

bioRxiv : the preprint server for biology·2026
Same author

Extracellular vesicles as novel mediators of pathology in Anderson-Fabry disease.

Clinical science (London, England : 1979)·2026
Same journal

Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis.

Cell stem cell·2026
Same journal

Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis.

Cell stem cell·2026
Same journal

Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation.

Cell stem cell·2026
Same journal

Paired pre- and post-transplant human immunoprofiling identifies an IFN-γ-JAK1 axis limiting stem-cell-derived RPE engraftment.

Cell stem cell·2026
Same journal

ENPP1 blockade with a humanized monoclonal antibody enhances renal repair after acute kidney injury.

Cell stem cell·2026
Same journal

ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation.

Cell stem cell·2026
See all related articles

Related Experiment Video

Updated: Apr 17, 2026

Tracheotomy: A Method for Transplantation of Stem Cells to the Lung
03:45

Tracheotomy: A Method for Transplantation of Stem Cells to the Lung

Published on: February 25, 2007

12.4K

A new notch for lung stem cells.

Gianni Carraro1, Barry R Stripp1

  • 1Departments of Medicine and Biomedical Sciences, Lung and Regenerative Medicine Institutes, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Cell Stem Cell
|February 7, 2015
PubMed
Summary
This summary is machine-generated.

Notch signaling controls the diversity and fate of basal stem cells in lung airways, crucial for tissue repair and homeostasis. This discovery aids understanding of lung regeneration and cell differentiation processes.

More Related Videos

Isolation & Characterization of Hoechstlow CD45negative Mouse Lung Mesenchymal Stem Cells
16:55

Isolation & Characterization of Hoechstlow CD45negative Mouse Lung Mesenchymal Stem Cells

Published on: October 26, 2011

21.0K
Isolation of CD133+ Liver Stem Cells for Clonal Expansion
12:06

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

22.9K

Related Experiment Videos

Last Updated: Apr 17, 2026

Tracheotomy: A Method for Transplantation of Stem Cells to the Lung
03:45

Tracheotomy: A Method for Transplantation of Stem Cells to the Lung

Published on: February 25, 2007

12.4K
Isolation & Characterization of Hoechstlow CD45negative Mouse Lung Mesenchymal Stem Cells
16:55

Isolation & Characterization of Hoechstlow CD45negative Mouse Lung Mesenchymal Stem Cells

Published on: October 26, 2011

21.0K
Isolation of CD133+ Liver Stem Cells for Clonal Expansion
12:06

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

22.9K

Area of Science:

  • Pulmonary Biology
  • Stem Cell Biology
  • Developmental Biology

Background:

  • Lung homeostasis and repair depend on progenitor/stem cells.
  • These cells must differentiate into specific types for regional lung functions.

Purpose of the Study:

  • To identify signaling pathways regulating progenitor cell heterogeneity.
  • To understand how these pathways influence cell fate decisions in lung airways.

Main Methods:

  • Investigated cell populations within pseudostratified airways.
  • Analyzed the role of Notch signaling in basal cell populations.

Main Results:

  • Notch signaling was identified as a key determinant of basal cell heterogeneity.
  • This pathway regulates the fate decisions of basal stem cells in the airways.

Conclusions:

  • Notch signaling plays a critical role in maintaining lung stem cell diversity.
  • Understanding this mechanism is vital for lung repair and regenerative medicine.