Adult atopic dermatitis: a review

Area of Science:

• Dermatology
• Immunology

Background:

• Atopic dermatitis (AD) is a chronic inflammatory skin condition, often starting in childhood.
• While frequently resolving in youth, AD can persist into adulthood or manifest later in life as late-onset AD.
• Increasing incidence of adult and late-onset AD contrasts with a scarcity of research on this demographic.

Purpose of the Study:

• To comprehensively review the diagnostic work-up for adult atopic dermatitis.
• To address the challenges posed by atypical presentations and lack of validated diagnostic criteria in adult AD.
• To explore epidemiological data, quality of life impacts, and pathogenic mechanisms specific to adult AD.

Main Methods:

• This review synthesizes existing literature on adult atopic dermatitis.
• It examines diagnostic criteria, epidemiological trends, and quality of life assessments.
• Pathogenesis of adult-onset and persistent adult AD is also discussed.

Main Results:

• Adult AD presents unique challenges, including nonflexural rash patterns and atypical morphologies.
• Validated diagnostic criteria and a clear consensus on work-up for adult AD are currently lacking.
• Epidemiological data indicate a rising incidence, particularly in industrialized nations.

Conclusions:

• There is a critical need for further research into adult atopic dermatitis.
• Development of specific diagnostic criteria and work-up protocols for adult AD is essential.
• Understanding the unique aspects of adult AD is crucial for effective management and treatment.