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Updated: Apr 17, 2026
07:06
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
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Recurrent Clostridium difficile infection is associated with increased mortality
Summary
Recurrent Clostridium difficile infections (CDI) significantly increase mortality risk. Patients experiencing recurrent CDI face a higher likelihood of death within six months compared to those with a single episode.
Area of Science:
- Infectious Diseases
- Epidemiology
- Clinical Medicine
Background:
- Clostridium difficile infections (CDI) are a significant cause of morbidity and mortality.
- Up to 30% of CDI patients experience recurrence, yet data on its impact on survival are limited.
Purpose of the Study:
- To investigate the independent association between recurrent CDI and 6-month survival.
- To compare mortality rates in patients with recurrent CDI versus those without recurrence.
Main Methods:
- Retrospective cohort study at an academic, urban, tertiary care hospital.
- Analysis of electronic medical records and chart review for 3958 adult patients with initial CDI episodes (2003-2009).
- Kaplan-Meier and Cox proportional hazards models used to assess mortality within 180 days, adjusting for covariates.
Main Results:
- 36% of patients with recurrent CDI died within 180 days, compared to 26% without recurrence (p <0.001).
- Recurrent CDI was independently associated with a 33% increased hazard of death within 180 days (HR 1.33; 95% CI 1.12-1.58).
Conclusions:
- Recurrent CDI is a significant independent risk factor for increased 6-month mortality.
- This finding underscores the importance of managing and preventing CDI recurrence to improve patient outcomes.
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