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Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
[Probiotics for the treatment of infant colic: a clinical case]
Jimena Pérez-Moreno1, Luz Taboada Castro2, Mar Tolín Hernani3
1Sección Gastroenterología y Nutrición Infantil. Hospital General Universitario Gregorio Marañón Madrid.. jimenapermor@gmail.com.
Insights
Infant colic, a common issue in babies, may be linked to gut bacteria imbalances. The probiotic strain L. reuteri DSM 17938 shows promise for treatment with no significant side effects.
Area of Science:
- Pediatrics
- Gastroenterology
- Microbiology
Background:
- Infant colic affects healthy infants under 3 months, causing distress.
- Its exact cause is unknown but is considered multifactorial, involving gut microbiota.
- While typically benign, colic can necessitate therapeutic interventions.
Purpose of the Study:
- To explore the role of gut microbiota in infant colic.
- To evaluate the efficacy of probiotic L. reuteri DSM 17938 in managing infant colic.
Main Methods:
- Review of existing studies on infant colic and gut microbiota.
- Analysis of the impact of L. reuteri DSM 17938 on colic symptoms.
Main Results:
- Infant colic is associated with reduced levels of beneficial bacteria like Bifidobacteria and Lactobacilli.
- An increased presence of bacteria such as Escherichia, Klebsiella, and Pseudomonas is observed.
- L. reuteri DSM 17938, at 10⁸ CFU/day, demonstrates significant scientific evidence for treating infant colic.
Conclusions:
- Gut microbiota composition is significantly altered in infants with colic.
- Probiotic L. reuteri DSM 17938 is a promising therapeutic option for infant colic.
- L. reuteri DSM 17938 is safe and effective for managing infant colic symptoms.
Abstract:
Infant colic is a prevalent physiological event of healthy children under 3 months of age which can disrupt the child's home environment. Despite its benign natural history, sometimes requires a therapeutic approach. Numerous therapeutical lines have been proposed although its pathogenesis remains unknown and multifactorial. The gut microbiota plays an important role in the infant colic. Several studies have shown less bifidobacteria and lactobacilli in infant colic meanwhile Escherichia, Klebsiella, Serratia, Vibrio, Yersinia and Pseudomonas are more prominent in colon. The probiotic strain L. reuteri DSM 17938, when administered once daily to 10⁸ cfu / day, seems to have the most scientific evidence up to date in the treatment of infant colic, without significant side effects.
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